Immediately Available Dry Computing Services
Not PPT visions — but engineered capabilities that are tested, verified, and deliverable
Neoantigen mRNA Vaccine 8-Step Pipeline
✓ VerifiedFrom VCF/BAM to mRNA sequence design, fully validated end-to-end. Three differentiators: pMHC 3D structure verification, 5-dimensional immunogenicity scoring, in-house RNALens fine-tuning. TESLA benchmark AUROC=0.698.
pMHC 3D Structure Prediction + Docking Validation
✓ VerifiedTraditional pipelines stop at IC50 values. DiVo Gen²AI uses Protenix to build atom-level pMHC 3D structures for each candidate neoantigen, validated by Protenix-Dock physical docking. 400+ complexes at scale.
Genome Interpretation Report (Bilingual)
✓ VerifiedVCF QC → VEP annotation → ANNOVAR functional annotation → ACMG classification → health report. Bilingual MD/HTML/PDF delivery, 12+ batches validated.
HLA Typing (Dual-Tool Cross-Validation)
✓ VerifiedOptiType + Polysolver dual-algorithm cross-validation, 4-digit resolution HLA-I typing. Provides基础 input for neoantigen pipelines, also independently deliverable.
mRNA Sequence Optimization (RNALens)
✓ VerifiedMRL prediction model fine-tuned in 3 stages on DNABERT-Z 117M — not a third-party API call. CAI 0.7→0.95, 3 tissue-adapted models (HEK/Muscle/PC3).
CAR-T Cell Therapy Computation
✓ VerifiedNeoantigen pipeline + RNA-seq surface antigen mining + de novo Binder design + structure validation. For medical institution partnerships, not direct-to-patient. Xie Qi / Cao Longxing Nature BME路线.
Aesthetic PRS · Genetic Beauty Profile
✓ VerifiedPolygenic risk scores for aesthetic targets — collagen loss, photoaging sensitivity, hair loss risk, pigmentation. PRSice-2+PRS-CS dual engine, Chinese population calibrated. B2B2C model — the tech backbone for aesthetic clinics.
Anti-Aging Peptide & Protein Engineering
✓ VerifiedFinding anti-aging molecules in 3D space — MMPs inhibitors, collagen engineering, Sirtuin activators. 100% tools deployed and validated: Protenix V2 + Pro-Prime + BoltzGen(5-weight complete) + ProteinMPNN + MHCflurry.
Skin Microbiome × Host Gene Joint Mining
✓ VerifiedSkin condition is a symbiotic result of genes and microbiota. 16S/ITS microbiome analysis (DADA2 local + MGnify online fallback) cross-mined with host HLA/FLG immune genes, revealing gene-microbiota-skin phenotype ternary relationships.
Follicle Induction · Five-Factor Combination
◈ ExploratoryFrom repair to regeneration — WNT10B+FGF9+Noggin+RSPO1+SHH-N five-factor combination inducing new follicles on hairless skin. Protenix V2 structure prediction + ProteinMPNN engineering design validated; mRNA delivery design (GEMORNA) ready. ARM mode: design only, no manufacturing.
ARCHITECTURE
四层业务能力架构
从硅片到信息载体 · 四层堆叠 · 四类用户各取所需
芯片与硬件及计算架构
Chip · Hardware · Computing Architecture自研处理器 + 端侧推理部署 + 云-端协同调度——从硅片到能跑软件的硬件，底层全栈掌控。
模型训练与微调及部署
Model Training · Fine-tuning · Deployment自研模型核心 · 蒸馏 · 微调 · 防逆向——不是调用第三方 API，是自主训练、自主部署、自主保护。
Agent 设计与部署
Agent Design & Deployment多 Agent 协作体系 · 管线编排 · 任务调度 · 自研 Agent 框架——让模型在具体业务场景中变成可执行的行动单元。
干计算服务
Dry Computation Services新生抗原管线 · VCF-Report · pMHC 结构预测 · mRNA 优化 · 基因组解读报告 · 科普与教育——交付给人类的信息载体。
面向四类用户
不同用户在不同层级找到价值
METHOD
DiVo Computing · 砥尚计算
Distributed Virtuous Computing — 分布式、有优雅而坚固的计算体系
Agentic Computing 的螺旋
不是单次计算，而是螺旋上升——信息数据化后进入计算，计算产出的数据再交付给人类时就是信息的载体，信息驱动更深的理解，更深的理解触发更精准的计算。DiVo Computing 是这个螺旋的工程化载体。
分布式 · Distributed
对抗结构刚性。单体算力有限、单点逻辑有偏——分布式体系让不同模型、不同工具、不同视角交叉验证，可靠性数量级提升。
有德性 · Virtuous
约束工具向善。计算不是目的，理解才是。我们拒绝制造 F_damage——不让技术成为伤害的放大器，让计算回归提升理解这一根本目的。
DiVo Gen²AI · 前沿 + 全能 · DiVo Computing 砥尚计算 · Understanding is All You Need
FOUNDATION
Understanding is All You Need.
帮助人类以科学的方式理解世界与自身，是我们全部的使命。
从基因组到蛋白质结构，从肿瘤突变到药物设计——用计算让复杂变得可理解。
每个人都是独特的——基因、免疫、代谢。真正的理解必须个体化，而非模板化。
理解不是为了控制，是为了选择。让个体在科学理解的基础上做出更好的生命决策。