Jueju.Wang
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Cathepsin D structure
P07339
CATD_HUMAN
CTSD

Cathepsin D

Homo sapiensTaxon: 9606

3D-structureAlzheimer diseaseAspartyl proteaseDirect protein sequencingDisease variantDisulfide bondGlycoproteinHydrolaseLysosomeNeurodegenerationNeuronal ceroid lipofuscinosisProtease+5
序列长度

412

氨基酸

分子量

44.6 kDa

理论值

实验结构

9

PDB 条目

相关疾病

1

已记录

功能描述

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease

定位与分布

组织特异性

Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530)

相关疾病

Ceroid lipofuscinosis, neuronal, 10

A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.

氨基酸序列

MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ

FASTA 格式 · 412 个氨基酸 · 分子量 44.6 kDa

实验结构

9 PDB 条目
1LYA1LYB1LYW4OBZ4OC64OD96QBG6QBH6QCB

翻译后修饰

  • •N- and O-glycosylated
  • •Undergoes proteolytic cleavage and activation by ADAM30
  • •As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified (PubMed:1426530). An additional form starting at Ala-168 has also been identified (PubMed:27333034)