P07477
TRY1_HUMANPRSS1
Serine protease 1
Homo sapiensTaxon: 9606
3D-structureCalciumDigestionDirect protein sequencingDisease variantDisulfide bondHydrolaseMetal-bindingProteaseProteomics identificationReference proteomeSecreted+4
序列长度
247
氨基酸
分子量
26.6 kDa
理论值
实验结构
12
PDB 条目
相关疾病
1
已记录
功能描述
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates
相关疾病
Pancreatitis, hereditary
A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.
氨基酸序列
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
FASTA 格式 · 247 个氨基酸 · 分子量 26.6 kDa
实验结构
12 PDB 条目1FXY1TRN2RA34WWY4WXV7QE87QE98H3S8ZI48ZIV8ZIY8ZJ4
翻译后修饰
- •Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122
- •Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins