Transcriptional activator Myb

Homo sapiensTaxon: 9606

AcetylationActivatorAlternative splicingDNA-bindingIsopeptide bondNucleusPhosphoproteinProteomics identificationProto-oncogeneReference proteomeRepeatTranscription+2

序列长度

640

氨基酸

分子量

72.3 kDa

理论值

实验结构

PDB 条目

功能描述

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells

氨基酸序列

MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT
DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK
HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA
IKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV

FASTA 格式 · 640 个氨基酸 · 分子量 72.3 kDa

翻译后修饰

•Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation
•SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition
•Phosphorylated by NLK on multiple sites, which induces proteasomal degradation
•Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels