
P02144
MYG_HUMANMB
Myoglobin
肌红蛋白
Homo sapiensTaxon: 9606
3D-structureCytoplasmDirect protein sequencingDisease variantHemeIronMetal-bindingMuscle proteinOxidoreductaseOxygen transportPhosphoproteinProteomics identification+2
서열 길이
154
아미노산
분자량
17.2 kDa
이론값
실험 구조
1
PDB 항목
관련 질환
1
기록됨
기능 설명
Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218)
单体血红素蛋白的主要功能是储存氧气并促进其在肌肉组织内的扩散。 通过五配位血红素铁可逆地结合氧气,并在需求增加期间根据需要及时有效地释放氧气(PubMed:30918256,PubMed:34679218)。 根据组织和细胞的氧化条件,除了其结合氧的能力外,它还具有亚硝酸还原酶活性,从而调节生物活性一氧化氮的产生 (PubMed:32891753)。 在缺氧和缺氧等应激条件下,由于其伪过氧化物酶活性,它还可以保护细胞免受活性氧的侵害 (PubMed:34679218)
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관련 질환
Myopathy, sarcoplasmic body
An autosomal dominant, slowly progressive muscle disorder manifesting in adulthood with proximal and axial weakness that progresses to involve distal muscles. Patients may lose ambulation after a long disease course, and some individuals develop respiratory or cardiac symptoms. Muscle pathology features include sarcoplasmic bodies in skeletal and cardiac muscles.
아미노산 서열
MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLFKGHPETLEKFDKFKHLKSEDEMKASE DLKKHGATVLTALGGILKKKGHHEAEIKPLAQSHATKHKIPVKYLEFISECIIQVLQSKH PGDFGADAQGAMNKALELFRKDMASNYKELGFQG
FASTA 형식 · 154 아미노산 · 분자량 17.2 kDa
실험 구조
1 PDB 항목3RGK