Jueju.Wang
지식 베이스 홈
Apolipoprotein B-100 structure
P04114
APOB_HUMAN
APOB

Apolipoprotein B-100

Homo sapiensTaxon: 9606

3D-structureAcetylationAtherosclerosisCholesterol metabolismChylomicronCytoplasmDirect protein sequencingDisease variantDisulfide bondGlycoproteinHeparin-bindingLDL+15
서열 길이

4563

아미노산

분자량

515.5 kDa

이론값

실험 구조

8

PDB 항목

관련 질환

2

기록됨

기능 설명

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor
载脂蛋白 B 是乳糜微粒 (apo B-48)、LDL (apo B-100) 和 VLDL (apo B-100) 的主要蛋白质成分。 Apo B-100 充当 apoB/E 受体对 LDL 颗粒的细胞结合和内化的识别信号
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관련 질환

Hypobetalipoproteinemia, familial, 1

A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia.

Hypercholesterolemia, familial, 2

A form of hypercholesterolemia, a disorder of lipoprotein metabolism characterized by elevated serum low-density lipoprotein (LDL) cholesterol levels, which result in excess deposition of cholesterol in tissues and leads to xanthelasma, xanthomas, accelerated atherosclerosis and increased risk of premature coronary heart disease. FHCL2 inheritance is autosomal dominant.

아미노산 서열

MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAES
SSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSE
EFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLFLD
TVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLIS

FASTA 형식 · 4563 아미노산 · 분자량 515.5 kDa

실험 구조

8 PDB 항목
9BD19BD89BDE9BDT9COO9E9R9EA79EAG

번역 후 수식

  • •Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle