Jueju.Wang
지식 베이스 홈
Cathepsin D structure
P07339
CATD_HUMAN
CTSD

Cathepsin D

Homo sapiensTaxon: 9606

3D-structureAlzheimer diseaseAspartyl proteaseDirect protein sequencingDisease variantDisulfide bondGlycoproteinHydrolaseLysosomeNeurodegenerationNeuronal ceroid lipofuscinosisProtease+5
서열 길이

412

아미노산

분자량

44.6 kDa

이론값

실험 구조

9

PDB 항목

관련 질환

1

기록됨

기능 설명

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease

국재 및 분포

조직 특이성

Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530)

관련 질환

Ceroid lipofuscinosis, neuronal, 10

A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.

아미노산 서열

MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ

FASTA 형식 · 412 아미노산 · 분자량 44.6 kDa

실험 구조

9 PDB 항목
1LYA1LYB1LYW4OBZ4OC64OD96QBG6QBH6QCB

번역 후 수식

  • •N- and O-glycosylated
  • •Undergoes proteolytic cleavage and activation by ADAM30
  • •As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified (PubMed:1426530). An additional form starting at Ala-168 has also been identified (PubMed:27333034)