Galectin-1

Homo sapiensTaxon: 9606

3D-structureAcetylationApoptosisCytoplasmDirect protein sequencingExtracellular matrixLectinPhosphoproteinProteomics identificationReference proteomeSecreted

서열 길이

135

아미노산

분자량

14.7 kDa

이론값

실험 구조

PDB 항목

기능 설명

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69 (PubMed:24752896)

국재 및 분포

조직 특이성

Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells

아미노산 서열

MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIV
CNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINY
MAADGDFKIKCVAFD

FASTA 형식 · 135 아미노산 · 분자량 14.7 kDa

실험 구조

39 PDB 항목

1GZW1W6M1W6N1W6O1W6P1W6Q2KM22ZKN3OY83OYW3T2T3W583W594Q1P4Q1R4Q264Q274Q2F4XBL4Y1U4Y1V4Y1X4Y1Y4Y1Z4Y204Y224Y245MWT5MWX6B946F836M5Y7LTA7NML8B0W8B0Z8OJP8R748RDC