Serglycin

Homo sapiensTaxon: 9606

ApoptosisBiomineralizationDirect protein sequencingDisulfide bondGlycoproteinGolgi apparatusLysosomeProteoglycanProteomics identificationReference proteomeRepeatSecreted+1

서열 길이

158

아미노산

분자량

17.7 kDa

이론값

실험 구조

PDB 항목

기능 설명

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF and may also regulate protease secretion. Inhibits bone mineralization

아미노산 서열

MMQKLLKCSRLVLALALILVLESSVQGYPTRRARYQWVRCNPDSNSANCLEEKGPMFELL
PGESNKIPRLRTDLFPKTRIQDLNRIFPLSEDYSGSGFGSGSGSGSGSGSGFLTEMEQDY
QLVDESDAFHDNLRSLDRNLPSDSQDLGQHGLEEDFML

FASTA 형식 · 158 아미노산 · 분자량 17.7 kDa

번역 후 수식

•O-glycosylated; contains chondroitin sulfate and heparan sulfate