Transcriptional activator Myb

Homo sapiensTaxon: 9606

AcetylationActivatorAlternative splicingDNA-bindingIsopeptide bondNucleusPhosphoproteinProteomics identificationProto-oncogeneReference proteomeRepeatTranscription+2

서열 길이

640

아미노산

분자량

72.3 kDa

이론값

실험 구조

PDB 항목

기능 설명

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells

아미노산 서열

MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT
DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK
HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA
IKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV

FASTA 형식 · 640 아미노산 · 분자량 72.3 kDa

번역 후 수식

•Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation
•SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition
•Phosphorylated by NLK on multiple sites, which induces proteasomal degradation
•Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels