Ras-related protein R-Ras

Homo sapiensTaxon: 9606

3D-structureCell membraneDirect protein sequencingGTP-bindingHydrolaseLipoproteinMembraneMethylationNucleotide-bindingPalmitatePrenylationProteomics identification+1

서열 길이

218

아미노산

분자량

23.5 kDa

이론값

실험 구조

PDB 항목

기능 설명

GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:39809765). Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267)

아미노산 서열

MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDP
TIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVG
KLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVD
EAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL

FASTA 형식 · 218 아미노산 · 분자량 23.5 kDa

실험 구조

2 PDB 항목

2FN47S0Z

번역 후 수식

•S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability