Immediately Available Dry Computing Services
Not PPT visions — but engineered capabilities that are tested, verified, and deliverable
Neoantigen mRNA Vaccine 8-Step Pipeline
✓ VerifiedFrom VCF/BAM to mRNA sequence design, fully validated end-to-end. Three differentiators: pMHC 3D structure verification, 5-dimensional immunogenicity scoring, in-house RNALens fine-tuning. TESLA benchmark AUROC=0.698.
pMHC 3D Structure Prediction + Docking Validation
✓ VerifiedTraditional pipelines stop at IC50 values. DiVo Gen²AI uses Protenix to build atom-level pMHC 3D structures for each candidate neoantigen, validated by Protenix-Dock physical docking. 400+ complexes at scale.
Genome Interpretation Report (Bilingual)
✓ VerifiedVCF QC → VEP annotation → ANNOVAR functional annotation → ACMG classification → health report. Bilingual MD/HTML/PDF delivery, 12+ batches validated.
HLA Typing (Dual-Tool Cross-Validation)
✓ VerifiedOptiType + Polysolver dual-algorithm cross-validation, 4-digit resolution HLA-I typing. Provides基础 input for neoantigen pipelines, also independently deliverable.
mRNA Sequence Optimization (RNALens)
✓ VerifiedMRL prediction model fine-tuned in 3 stages on DNABERT-Z 117M — not a third-party API call. CAI 0.7→0.95, 3 tissue-adapted models (HEK/Muscle/PC3).
CAR-T Cell Therapy Computation
✓ VerifiedNeoantigen pipeline + RNA-seq surface antigen mining + de novo Binder design + structure validation. For medical institution partnerships, not direct-to-patient. Xie Qi / Cao Longxing Nature BME路线.
Aesthetic PRS · Genetic Beauty Profile
✓ VerifiedPolygenic risk scores for aesthetic targets — collagen loss, photoaging sensitivity, hair loss risk, pigmentation. PRSice-2+PRS-CS dual engine, Chinese population calibrated. B2B2C model — the tech backbone for aesthetic clinics.
Anti-Aging Peptide & Protein Engineering
✓ VerifiedFinding anti-aging molecules in 3D space — MMPs inhibitors, collagen engineering, Sirtuin activators. 100% tools deployed and validated: Protenix V2 + Pro-Prime + BoltzGen(5-weight complete) + ProteinMPNN + MHCflurry.
Skin Microbiome × Host Gene Joint Mining
✓ VerifiedSkin condition is a symbiotic result of genes and microbiota. 16S/ITS microbiome analysis (DADA2 local + MGnify online fallback) cross-mined with host HLA/FLG immune genes, revealing gene-microbiota-skin phenotype ternary relationships.
Follicle Induction · Five-Factor Combination
◈ ExploratoryFrom repair to regeneration — WNT10B+FGF9+Noggin+RSPO1+SHH-N five-factor combination inducing new follicles on hairless skin. Protenix V2 structure prediction + ProteinMPNN engineering design validated; mRNA delivery design (GEMORNA) ready. ARM mode: design only, no manufacturing.
ARCHITECTURE
Four-Layer Business Architecture
From silicon to information carrier · Four layers stacked · Four user types, each finds value
Chip, Hardware & Computing Architecture
Chip · Hardware · Computing ArchitectureSelf-developed processors + edge inference deployment + cloud-edge collaborative scheduling — full-stack control from silicon to hardware that runs software.
Model Training, Fine-tuning & Deployment
Model Training · Fine-tuning · DeploymentSelf-developed model core · distillation · fine-tuning · anti-reverse engineering — not calling third-party APIs, but autonomous training, deployment, and protection.
Agent Design & Deployment
Agent Design · DeploymentMulti-agent collaboration · pipeline orchestration · task scheduling · self-developed Agent framework — turning models into executable action units in specific business scenarios.
Dry Computation Services
Dry Computation ServicesNeoantigen pipeline · VCF-Report · pMHC structure prediction · mRNA optimization · Genome interpretation report · Science education — information carriers delivered to humans.
For Four User Types
Different users find value at different layers
Research
Research
Chip architecture collaboration · Joint model R&D · Full-stack tech integration
Enterprise/Pharma
Enterprise
Custom hardware deployment · Model privatization · Agent customization · Batch pipeline delivery
Medical
Medical
Neoantigen pipeline · Genome reports · Clinical-grade dry computation services
Personal/C-End
Personal
Four-dimensional digital twin · Genome interpretation · Science education
rvdon
RVDon — Open-source RISC-V GPGPU processor with PF extension ISA, native support for Flash Attention and triangular mask matrix multiplication, hardware acceleration foundation for protein structure prediction.
GitHub →rvdon-kahan
RVDon-Kahan — Kahan compensated summation algorithm hardware acceleration, forming a hardcore open source duo with RVDon, providing precision guarantees for numerically intensive computing.
GitHub →