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It must be said that from a young age she already harbored suicidal thoughts and impulses, which were clearly signs of some mental disorder, but in the 1970s such things went unrecognized.According to later recollections by Robert Leadbetter, when he and Barbara Yung were dating, her mother initiall…

After much thought, I kept wondering what title would best close this book. I think I'll use "My apology to myself outweighs that to all of you present, except my two sons." Though my mind is now elated, even hypomanic, recalling this title brings tears to my eyes; let them fall freely with the clat…

There is a saying that goes,'Ever since I got mentally ill, I feel so much more spirited!'For many patients with bipolar disorder, this really hits the nail on the head—though only during their hypomanic or manic episodes.Then for those suffering from depression, perhaps it is that, after developing…

Neurobiology of Suicidal Behavior   Abstract   This report comprehensively reviews advances in the neuroscience of suicidal behavior from 2000 to 2025. It systematically integrates findings on core neurobiological mechanisms, including dysfunctional neural circuits, neurotransmitter system…

  Wittgenstein on Suicide: A Deep Philosophical Research Report   Abstract   Ludwig Wittgenstein, one of the most influential philosophers of the 20th century, did not treat suicide as an isolated ethical question. Rather, his view is deeply interwoven with his personal biography, his…

  Schopenhauer on Suicide: A Final Misjudgment of the Will-to-Live   Abstract: In Western philosophy, Arthur Schopenhauer (1788-1860) is famous for his profound pessimism. He sees the world as a realm driven by a blind, irrational "Will-to-Live," full of endless suffering and struggle. Und…

The following is an excerpt from Freud's biography: Scientists ran many experiments testing Freud's doctrines. In 1934 Freud wrote to psychologist Saul Rosenzweig that his theories were "irrelevant to experimental verification." Hans Eysenck, in Decline and Fall of the Freudian Empire (1985), critic…

At first I had the AI study the suicide risk of bipolar disorder—mainly because of its high misdiagnosis rate and long diagnostic delay, which made me want to quantify the harm of misdiagnosis through suicide risk, since I myself was misdiagnosed with depression by a renowned top psychiatric hospita…

Pathophysiological Mechanisms and Genetics of Major Depressive Disorder (MDD): A Multidimensional Systematic Review     Abstract   Major depressive disorder (MDD) is a global, disabling mental illness whose impact extends from the emotional and cognitive levels to overall bodily funct…

Neuroimaging of Suicidal Thoughts and Behaviors: A Two-Decade Review Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies Lianne Schmaal, Anne-Laura van Harmelen, Vasiliki Chatzi, Elizabeth T. C. Lippard, Yara J. Toenders, Lynnette A. Averill, Carolyn …

Actually, at first I had no plan to write this booklet; I only meant to put my study materials and research reports on bipolar disorder and related mental disorders onto this independent site, bd.wangjueju.cn. But as my study and research deepened, I felt I should write a booklet—something tens of t…

This review notes: 90% of suicides occur in people with mental disorders, and over 50% of those who die by suicide have major depressive disorder or bipolar disorder. Earlier, we also used AI to summarize the suicide risk in patients with various mental disorders.   Suicide, Neuroinflammation, …

Earlier we looked at the suicide risk in bipolar disorder; now that this series is retitled The Science of Suicide, it is worth examining the suicide risk of other mental disorders. The logic is simple: suicide is a behavior and thus a symptom of a mental disorder, and we can study these disorders—a…

Today a Q&A site pushed a notice that Ryoko Hirosue was arrested. Hirosue is a Japanese actress and singer I like a lot—she acts in normal films and shows, sings. I recall that when I first built websites around 2003, there was perhaps a downloads section of celebrity photo collections, which gather…

Nietzsche said, God is dead. Therefore we can say that life and suicide have moved beyond the realm of gods, theology, and religion.Then, going even further, Hawking took it a step further and said, 'Philosophy is dead!' So in fact there is not much need to fuss over those philosophical matters.Even…

In the first chapter of The Myth of Sisyphus, "Absurdity and Suicide," besides the line I detest—"society has little to do with this (suicide)"—there is one worthwhile passage: Those who commit suicide are often most certain of the meaning of life. It comes from this digression: Tracing back and rev…

Background Waking today in a daze, I still could not stomach Camus's line that "society has little to do with it (suicide)." Clinging to the hope that it might be a translation problem by Shen Zhiming — though such an obvious sentence should hardly be mistranslated — I searched online for the French…

Why spend tens of thousands of words on the "self-evident" absurdity and suicide? To be honest, I originally thought Camus's "The only serious philosophical problem is suicide. Judging whether life is worth living answers the fundamental question of philosophy." was a serious theory, with profound s…

In the second chapter of The Myth of Sisyphus, "The Absurd Man," Camus has a passage that made me feel he had become a bit of a detox master: Look, take trees: I know their roughness, their moisture, I can smell them. The fragrance of grass, the scent of stars, certain calm nights—how could I deny t…

  Practical New Therapies and Technologies for Bipolar Disorder Based on Neural Repair Abstract Bipolar Disorder (BD) is a complex chronic neuropsychiatric illness characterized by marked fluctuations in mood, thought, behavior, and energy level. Traditional treatments (such as mood stabilizers…

  Advances in Neural Repair Research: Neuronal Regeneration and Synaptic Plasticity     Abstract   Damage and disease of the nervous system are leading global causes of disability, imposing a heavy burden on patients' quality of life and on society and the economy. This report ex…

The Absurd and Suicide There is but one truly serious philosophical problem, and that is suicide. To judge whether life is worth living is to answer the fundamental question of philosophy. Whether the world has three dimensions, or the mind ranks in orders—all that is child's play beside the need fo…

Just now I saw an introduction to a study on neural repair. I haven't read it carefully, but its subjects are brain scans of meditating and Zen monks, which naturally piqued my interest. My first reaction was that this is an unscientific, or insufficiently scientific, study. Because earlier, when I …

Personal Note I originally asked grok3 to study in depth how suicide risk manifests in BD patients. I wanted to know whether, beyond the generally known fact that patients show strong suicide risk during depressive episodes, suicide risk also exists in other episode states, because after all, as the…

The school of psychoanalysis is the kind of thing that began with good intentions but later turned into a pile of garbage in practice. Many schools and theories in psychology are like this. Take a look at the scientific evaluation of psychology's schools and the history of psychology that the AI mad…

The second piece was long confused in my mind, because suicide is not an easy topic to write about. But today two Q&A-platform questions gave me inspiration. One asked: Should euthanasia be legalized? The other asked, roughly, what freedom really is. These two answers are related. First, in my v…

U.S. Brain Science Research: Planning, Progress, and a Historical Report Executive Summary This report chronologically details the evolution of U.S. brain-science research, from the mid-20th-century emergence of the discipline to today's large-scale, multi-institution collaboration. It traces the ri…

This paper, along with the 2025 study that used genomic methods to find some 30 genes and 300 associated genes, differs somewhat in method. But the logic is clear: genetic variants in the genome are expressed, forming the brain's structure—most critically the white matter, the "connectome," the neur…

Once I came across a so-called book on personality theory in the market, and saw some commercial online questionnaires for personality tests. It suddenly reminded me of a word: "psychology charlatan," the counterpart of "charlatan." Twenty years ago, studying the history of psychology was mainly to …

Camus opens The Myth of Sisyphus by stating: "The only serious philosophical question is suicide." He holds that people live every day, but when they begin to question "why," they enter the "absurd." This sense of absurdity comes from the conflict between the human pursuit of meaning and the impossi…

精神分析学派人格理论的深入探讨与科学性评价 本报告旨在深入探讨精神分析学派的核心人格理论，并对其进行全面的科学性评价。报告首先概述了精神分析学派的起源与发展脉络，从西格蒙德·弗洛伊德的经典理论（包括人格结构模型、心理性欲发展阶段和防御机制）出发，逐步阐述了卡尔·荣格、阿尔弗雷德·阿德勒、卡伦·霍妮、埃里希·弗洛姆、梅兰妮·克莱因、海因茨·科胡特和埃里克·埃里克森等后继理论家对精神分析思想的拓展与演变。报告随后对这些理论进行了严谨的科学性评价，涵盖了实证研究支持、方法论局限性、跨文化适用性以及与现代心理学和神经科学的对话。研究发现，尽管经典精神分析理论在可证伪性、经验证据和跨文化普适性方面面临挑…

The relationship between the definition of consciousness and nervous system development Introduction Consciousness is central to human experience, involving awareness of one's existence, thoughts, and environment. Understanding how it forms during nervous-system development is a major neuroscience q…

In the in-depth study of bipolar disorder, the psychotherapy mentioned highest is CBT. I don't know whether this so-called CBT works. I find its claim of "changing the way you think and act can help improve how you feel" unconvincing, as is the chaos of the domestic counseling-services industry, whi…

Mental disorder [1][2][3][4], also often called psychological disorder [5], mental illness [6], or psychological disease [7], is a general term for a class of diseases whose main symptom is mental disturbance [6]—that is, the disruption or abnormality of perceptual, cognitive, emotional, behavioral,…

The reason I rated this book low is that I felt it was full of "empty talk" (Seung's TED talk also reminded me of this point). As a bioinformatician, I understand the hype that surrounded the Human Genome Project at the time. We can sequence a person for less than a year's salary, yet not all geneti…

In our discussion of the harms of misdiagnosing bipolar disorder, we mentioned that if bipolar depression is treated with antidepressants, it may worsen the ensuing manic/hypomanic episode. Therefore, the general recommendation is that bipolar patients take a mood stabilizer—namely lithium carbonate…

  人类神经系统发育详尽报告 注: 《有关神经系统科学基本原理的信息》，谷歌gemini2.5这个研究报告有详细的分子过程。下一步我们将转向有关“连接组学”的研究。 人类神经系统是生物学中最复杂的结构之一，其发育过程是一个从受精后不久开始，持续到成年期的漫长而精密的旅程。这一过程涉及神经元和胶质细胞的精确生成、迁移、分化、成熟、突触形成与修剪以及髓鞘化，所有这些都由复杂的内在遗传程序和外在环境线索所引导。对这一复杂发育过程的深入理解，对于揭示脑功能、诊断和治疗神经发育障碍至关重要。   一、引言     人类神经系统发育概述   人类神经系统从…

On the Connectome: For a long time it was believed that many brain disorders—autism, schizophrenia and others—arise from faulty connections among nerve cells. Countless filamentous fibers crisscross the brain, forming a complex network that relays information between regions. Scientists call this si…

Key points Studies suggest exercise may ease depressive mood during bipolar depressive episodes, but evidence is limited and needs more research. Exercise seems to act through neurogenesis, reduced inflammation, and enhanced reward response. Whether exercise can trigger manic symptoms is debated; pl…

First, as I wrote in "Bipolar disorder has nothing to do with your so-called 'genius disease'!!!", I hope no one deifies or mythologizes him—just as I dislike any such treatment of any mental-illness patient. Yet for Hai Zi, entering Peking University at 15 was still impressive. Born in 1964, he was…

Because I saw several question askers on a Q&A platform phrase it this way in their question,'I had depression first, then it later turned into bipolar disorder.'Since I have after all written an article 'Misdiagnosis of Bipolar Disorder' and another 'The Harms of Misdiagnosing Bipolar Disorder', I …

Editor's note by Teacher George: This is to respond to the many people online asking whether bipolar people can date, whether one can stay with a bipolar girlfriend or boyfriend, and so on. Also, a classmate once called me self-centered and unable to love others during a discussion. But I don't thin…

Note: This research report was generated by XAI. Overview Bipolar disorder, a mental illness marked by extreme mood swings, is sometimes thought to be linked to creativity or high intelligence, and is therefore nicknamed the "genius disease." Yet this label is not an official medical term, and it is…

From the three images below we can see neurons, neurons with neuroglia and support cells, and neurotransmitter transmission between neurons. This is a neuron, which has a cell body and protrusions; the short protrusions are called dendrites, and the long protrusion is called an axon.A synapse i…

First is misdiagnosis.As studied in the previous article 'Be Alert to Misdiagnosis of Bipolar Disorder'The average time from a patient's first onset to confirmed diagnosis of bipolar disorder is 5–10 years, and over 1/3 of patients need 10 years or more to be diagnosed.Know why? Because bipolar is u…

I previously watched a video mentioning the possibility of the gut–brain axis for autism, and today I read a published genomic study on bipolar disorder that also mentioned this mechanism.But overall it still feels rather unreliable. More research evidence and clinical evidence are needed.However, p…

Perhaps the mental illness you are being treated for is not the one you actually have.And the mental illness you are diagnosed and treated for may instead worsen your real mental illness—the onset and risk of bipolar disorder.The misdiagnosis rate of bipolar disorder is relatively high, with widespr…

Mindfulness, meditation, zen, sitting, living in the present—I feel they all have one source, which is Buddhist meditation.But when I criticized the book “The Power of Now”, I already developed deep doubts about these. So I asked Google AI to do an in-depth study of mindfulness and write the review …

After all, the most critical pathogenic factor of this disease is the genetic factor.In the systematic study “Bipolar Disorder: Clinical Manifestations, Pathophysiology, Treatment Strategies, and Frontier Advances” it is pointed out thatThe etiology of bipolar disorder is a complex, multifactorial f…

First, remember: bipolar disorder is a mental disability.Second, among tens of millions of bipolar patients, only a very few can occasionally make special academic, artistic, or other contributions and show so-called “genius.” But their lives themselves are also abnormal and easily unhappy.Where mos…

In my comment on the previous study I mentioned:In modern psychology, personality is understood as the stable attitude an individual forms toward people, things, and oneself in social practice activities, and the corresponding habituated way of behaving. It is the most prominent and core aspect of p…

The most crucial point:In modern psychology, personality is understood as the stable attitude an individual forms toward people, things, and oneself in social practice activities, and the corresponding habituated way of behaving. It is the most prominent and core aspect of personality. Personality r…

“The only serious philosophical problem is suicide.” (The Myth of Sisyphus) — CamusMy feeling is that much fear comes from the pursuit of self-esteem and image, caring about others' views, fearing impact on relationships, business, etc.But the most serious issue in bipolar depressive episodes, among…

The main cause of bipolar is genetic, from the family.But more seriously, after onset, family members, especially parents and the older generation, not understanding—even blaming—is a more serious problem.I won't expand on this here.

Only since yesterday did I suddenly realize: it is not that I do not want to do marketing, it is that I do not want to keep working in the 'mental-health industry.'Five years into the industry, I started out relying on my several years of depression experience and social-media experience, entering t…

https://www.who.int/zh/news-room/fact-sheets/detail/bipolar-disorder Key facts Bipolar disorder is a mental health condition that affects a person's mood, energy, activity and thinking, marked by episodes of mania (or hypomania) and depression. An estimated 40 million people worldwide live with bipo…

Bipolar Disorder: A Systematic Study of Clinical Manifestations, Pathophysiology, Treatment Strategies, and Frontier Advances Abstract Bipolar disorder is a serious mental illness marked by periodic, intense fluctuations in mood, energy, and function, from manic/hypomanic to major depressive episode…

The transition from a depressive episode to a normal mood, or to hypomania, is inexplicably unpleasant.Indescribable?Like being sealed inside a cocoon?Especially miserable, right?But others cannot understand, and of course in such a state one is unwilling to tell outsiders.In fact, during a depressi…

The thing about this Heart Sutra is mainly that I do not know what 'Prajñāpāramitā' is—that is, the 'prajñā wisdom' practiced by Bodhisattva Avalokiteśvara. What kind of concept is it? But this prajñā wisdom is the very thing that 'illuminates the emptiness of the five aggregates and transcends all …

I feel this book is overrated. By denying the existence of the objective, natural, physical brain to assert a transcendent "ontology," it is hard to understand. I've read many glowing reviews saying that reading it during a depressive period felt good and useful. But I don't know why, when I read it…

Build a dedicated site about bipolar (affective) disorder.