Serotransferrin

血清转铁蛋白

Homo sapiensTaxon: 9606

3D-structureDirect protein sequencingDisease variantDisulfide bondGlycoproteinIon transportIronIron transportMetal-bindingMethylationPhosphoproteinProteomics identification+5

Longueur de Séquence

698

acides aminés

Poids Moléculaire

77.1 kDa

théorique

Structures Expérimentales

entrées PDB

Maladies Associées

enregistrées

Fonction

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use (Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use

转铁蛋白是铁结合转运蛋白，可以结合两个 Fe(3+) 离子，并与阴离子（通常是碳酸氢根）结合。它负责将铁从吸收和血红素降解部位运输到储存和利用部位。血清转铁蛋白还可能在刺激细胞增殖方面发挥进一步作用（微生物感染）作为奈瑟菌属物种的铁源，奈瑟菌属物种捕获蛋白质并提取铁供自己使用（微生物感染）作为寄生虫 T.brucei（菌株 427）的铁源，该寄生虫通过其自身的转铁蛋白受体 ESAG6:ESAG7 捕获 TF 并提取铁供自己使用

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Localisation & Distribution

Spécificité Tissulaire

Expressed by the liver and secreted in plasma

Maladies Associées

Atransferrinemia

A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia.

Séquence d'Acides Aminés

MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVK
KASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVV
KKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPC
ADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRD

Format FASTA · 698 acides aminés · masse 77.1 kDa

Structures Expérimentales

50 entrées PDB

1A8E1A8F1B3E1BP51BTJ1D3K1D4N1DTG1FQE1FQF1JQF1N7W1N7X1N841OQG1OQH1RYO1SUV2HAU2HAV2O7U2O843FGS3QYT3S9L3S9M3S9N3SKP3V833V893V8X3VE14H0W4X1B4X1D5DYH5H525WTD5X5P5Y6K6CTC6D036D046D056JAS6SOY6SOZ6UJ67FFM7FFU