Superoxide dismutase [Mn], mitochondrial

Homo sapiensTaxon: 9606

3D-structureAcetylationAlternative splicingDirect protein sequencingManganeseMetal-bindingMitochondrionNitrationOxidoreductaseProteomics identificationReference proteomeTransit peptide+1

Longueur de Séquence

222

acides aminés

Poids Moléculaire

24.8 kDa

théorique

Structures Expérimentales

entrées PDB

Maladies Associées

enregistrées

Fonction

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems

Maladies Associées

Microvascular complications of diabetes 6

Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

Séquence d'Acides Aminés

MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

Format FASTA · 222 acides aminés · masse 24.8 kDa

Structures Expérimentales

48 entrées PDB

1AP51AP61EM11JA81LUV1LUW1MSD1N0J1N0N1PL41PM91QNM1SZX1VAR1XDC1XIL1ZSP1ZTE1ZUQ2ADP2ADQ2GDS2P4K2QKA2QKC3C3S3C3T5GXO5T305VF97KKS7KKU7KKW7KLB8SKS8VHW8VHY8VJ08VJ48VJ58VJ89BVY9BW29BWM9BWQ9BWR9NR09NSJ

Modifications Post-Traductionnelles

•Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity
•Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity)
•Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability