Serine protease 1

Homo sapiensTaxon: 9606

3D-structureCalciumDigestionDirect protein sequencingDisease variantDisulfide bondHydrolaseMetal-bindingProteaseProteomics identificationReference proteomeSecreted+4

Longueur de Séquence

247

acides aminés

Poids Moléculaire

26.6 kDa

théorique

Structures Expérimentales

entrées PDB

Maladies Associées

enregistrées

Fonction

Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates

Maladies Associées

Pancreatitis, hereditary

A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.

Séquence d'Acides Aminés

MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK

Format FASTA · 247 acides aminés · masse 26.6 kDa

Structures Expérimentales

12 entrées PDB

1FXY1TRN2RA34WWY4WXV7QE87QE98H3S8ZI48ZIV8ZIY8ZJ4

Modifications Post-Traductionnelles

•Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122
•Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins