Serglycin

Homo sapiensTaxon: 9606

ApoptosisBiomineralizationDirect protein sequencingDisulfide bondGlycoproteinGolgi apparatusLysosomeProteoglycanProteomics identificationReference proteomeRepeatSecreted+1

Longueur de Séquence

158

acides aminés

Poids Moléculaire

17.7 kDa

théorique

Structures Expérimentales

entrées PDB

Maladies Associées

enregistrées

Fonction

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF and may also regulate protease secretion. Inhibits bone mineralization

Séquence d'Acides Aminés

MMQKLLKCSRLVLALALILVLESSVQGYPTRRARYQWVRCNPDSNSANCLEEKGPMFELL
PGESNKIPRLRTDLFPKTRIQDLNRIFPLSEDYSGSGFGSGSGSGSGSGSGFLTEMEQDY
QLVDESDAFHDNLRSLDRNLPSDSQDLGQHGLEEDFML

Format FASTA · 158 acides aminés · masse 17.7 kDa

Modifications Post-Traductionnelles

•O-glycosylated; contains chondroitin sulfate and heparan sulfate