Transcriptional activator Myb

Homo sapiensTaxon: 9606

AcetylationActivatorAlternative splicingDNA-bindingIsopeptide bondNucleusPhosphoproteinProteomics identificationProto-oncogeneReference proteomeRepeatTranscription+2

Longueur de Séquence

640

acides aminés

Poids Moléculaire

72.3 kDa

théorique

Structures Expérimentales

entrées PDB

Maladies Associées

enregistrées

Fonction

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells

Séquence d'Acides Aminés

MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT
DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK
HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA
IKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV

Format FASTA · 640 acides aminés · masse 72.3 kDa

Modifications Post-Traductionnelles

•Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation
•SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition
•Phosphorylated by NLK on multiple sites, which induces proteasomal degradation
•Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels