Ras-related protein R-Ras

Homo sapiensTaxon: 9606

3D-structureCell membraneDirect protein sequencingGTP-bindingHydrolaseLipoproteinMembraneMethylationNucleotide-bindingPalmitatePrenylationProteomics identification+1

Longueur de Séquence

218

acides aminés

Poids Moléculaire

23.5 kDa

théorique

Structures Expérimentales

entrées PDB

Maladies Associées

enregistrées

Fonction

GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:39809765). Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267)

Séquence d'Acides Aminés

MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDP
TIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVG
KLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVD
EAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL

Format FASTA · 218 acides aminés · masse 23.5 kDa

Structures Expérimentales

2 entrées PDB

2FN47S0Z

Modifications Post-Traductionnelles

•S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability