Catalase

过氧化氢酶

Homo sapiensTaxon: 9606

3D-structureAcetylationDirect protein sequencingHemeHydrogen peroxideIronMetal-bindingMitogenNADPOxidoreductasePeroxidasePeroxisome+3

Sequence Length

527

amino acids

Molecular Weight

59.8 kDa

theoretical

Experimental Structures

PDB entries

Related Diseases

recorded

Function

Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369)

催化过氧化物酶体氧化酶产生的过氧化氢 (H(2)O(2)) 降解为水和氧气，从而保护细胞免受过氧化氢的毒性作用 (PubMed:7882369)。促进细胞生长，包括 T 细胞、B 细胞、骨髓性白血病细胞、黑色素瘤细胞、肥大细胞瘤细胞以及正常和转化的成纤维细胞 (PubMed:7882369)

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Related Diseases

Acatalasemia

A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait.

Amino Acid Sequence

MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ

FASTA format · 527 amino acids · mass 59.8 kDa

Experimental Structures

16 PDB entries

1DGB1DGF1DGG1DGH1F4J1QQW7P8W7VD98EL98HID8PVD8SGV8WZH8WZJ8WZK8WZM