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S3
mRNA Vaccine / Drug Design
CDS + 5'UTR + 3'UTR full coverage
GEMORNA three-module design, three-tier UTR for different expression needs. Immunogenicity assessed at design stage.
2-3 weeks150K-500K/projectCapability Coverage 95%
Pipeline Flow
End-to-end dry-computing loop
1
CDS Codon Optimization
DNAChisel target sequence codon optimization
2
5'UTR Design
Three-tier UTR: strong/medium/weak expression
3
3'UTR Design
Stability + expression dual optimization
4
mRNA Structure Prediction
ViennaRNA predicts complete mRNA secondary structure
5
Immunogenicity Assessment
MHCflurry predicts MHC binding affinity
6
Antigen Structure Prediction
ESMFold predicts antigen protein 3D structure
7
Synthesis-ready
Complete mRNA sequence + structure validation + immunogenicity score
Core Tools
GEMORNADNAChiselViennaRNAESMFoldMHCflurryProteinMPNN
Core Advantages
GEMORNA Three-module
CDS + UTR + immunogenicity integrated design
Three-tier UTR
Strong/medium/weak three tiers, not generic templates
Front-loaded Immunogenicity
Assessed at design stage
Capability Coverage
95%Start Your Project mRNA Vaccine / Drug Design
Start with just 1 project, no team needed.