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Apolipoprotein B-100 structure
P04114
APOB_HUMAN
APOB

Apolipoprotein B-100

Homo sapiensTaxon: 9606

3D-structureAcetylationAtherosclerosisCholesterol metabolismChylomicronCytoplasmDirect protein sequencingDisease variantDisulfide bondGlycoproteinHeparin-bindingLDL+15
Sequence Length

4563

amino acids

Molecular Weight

515.5 kDa

theoretical

Experimental Structures

8

PDB entries

Related Diseases

2

recorded

Function

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor
载脂蛋白 B 是乳糜微粒 (apo B-48)、LDL (apo B-100) 和 VLDL (apo B-100) 的主要蛋白质成分。 Apo B-100 充当 apoB/E 受体对 LDL 颗粒的细胞结合和内化的识别信号
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Related Diseases

Hypobetalipoproteinemia, familial, 1

A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia.

Hypercholesterolemia, familial, 2

A form of hypercholesterolemia, a disorder of lipoprotein metabolism characterized by elevated serum low-density lipoprotein (LDL) cholesterol levels, which result in excess deposition of cholesterol in tissues and leads to xanthelasma, xanthomas, accelerated atherosclerosis and increased risk of premature coronary heart disease. FHCL2 inheritance is autosomal dominant.

Amino Acid Sequence

MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAES
SSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSE
EFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLFLD
TVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLIS

FASTA format · 4563 amino acids · mass 515.5 kDa

Experimental Structures

8 PDB entries
9BD19BD89BDE9BDT9COO9E9R9EA79EAG

Post-Translational Modifications

  • •Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle