Serine protease 1

Homo sapiensTaxon: 9606

3D-structureCalciumDigestionDirect protein sequencingDisease variantDisulfide bondHydrolaseMetal-bindingProteaseProteomics identificationReference proteomeSecreted+4

Sequence Length

247

amino acids

Molecular Weight

26.6 kDa

theoretical

Experimental Structures

PDB entries

Related Diseases

recorded

Function

Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates

Related Diseases

Pancreatitis, hereditary

A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.

Amino Acid Sequence

MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK

FASTA format · 247 amino acids · mass 26.6 kDa

Experimental Structures

12 PDB entries

1FXY1TRN2RA34WWY4WXV7QE87QE98H3S8ZI48ZIV8ZIY8ZJ4

Post-Translational Modifications

•Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122
•Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins