Matrilysin

Homo sapiensTaxon: 9606

3D-structureCalciumCollagen degradationDirect protein sequencingExtracellular matrixHydrolaseMetal-bindingMetalloproteaseProteaseProteomics identificationReference proteomeSecreted+3

Sequence Length

267

amino acids

Molecular Weight

29.7 kDa

theoretical

Experimental Structures

PDB entries

Related Diseases

recorded

Function

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase

Amino Acid Sequence

MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK
EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDL
PHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAF
APGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGD

FASTA format · 267 amino acids · mass 29.7 kDa

Experimental Structures

16 PDB entries

1MMP1MMQ1MMR2DDY2MZE2MZH2MZI2Y6C2Y6D5UE25UE57WXX8JUD8JUF8JUG8K4Z