Galectin-1

Homo sapiensTaxon: 9606

3D-structureAcetylationApoptosisCytoplasmDirect protein sequencingExtracellular matrixLectinPhosphoproteinProteomics identificationReference proteomeSecreted

Sequence Length

135

amino acids

Molecular Weight

14.7 kDa

theoretical

Experimental Structures

PDB entries

Related Diseases

recorded

Function

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69 (PubMed:24752896)

Localization & Distribution

Tissue Specificity

Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells

Amino Acid Sequence

MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIV
CNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINY
MAADGDFKIKCVAFD

FASTA format · 135 amino acids · mass 14.7 kDa

Experimental Structures

39 PDB entries

1GZW1W6M1W6N1W6O1W6P1W6Q2KM22ZKN3OY83OYW3T2T3W583W594Q1P4Q1R4Q264Q274Q2F4XBL4Y1U4Y1V4Y1X4Y1Y4Y1Z4Y204Y224Y245MWT5MWX6B946F836M5Y7LTA7NML8B0W8B0Z8OJP8R748RDC