Serglycin

Homo sapiensTaxon: 9606

ApoptosisBiomineralizationDirect protein sequencingDisulfide bondGlycoproteinGolgi apparatusLysosomeProteoglycanProteomics identificationReference proteomeRepeatSecreted+1

Sequence Length

158

amino acids

Molecular Weight

17.7 kDa

theoretical

Experimental Structures

PDB entries

Related Diseases

recorded

Function

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF and may also regulate protease secretion. Inhibits bone mineralization

Amino Acid Sequence

MMQKLLKCSRLVLALALILVLESSVQGYPTRRARYQWVRCNPDSNSANCLEEKGPMFELL
PGESNKIPRLRTDLFPKTRIQDLNRIFPLSEDYSGSGFGSGSGSGSGSGSGFLTEMEQDY
QLVDESDAFHDNLRSLDRNLPSDSQDLGQHGLEEDFML

FASTA format · 158 amino acids · mass 17.7 kDa

Post-Translational Modifications

•O-glycosylated; contains chondroitin sulfate and heparan sulfate