Transcriptional activator Myb

Homo sapiensTaxon: 9606

AcetylationActivatorAlternative splicingDNA-bindingIsopeptide bondNucleusPhosphoproteinProteomics identificationProto-oncogeneReference proteomeRepeatTranscription+2

Sequence Length

640

amino acids

Molecular Weight

72.3 kDa

theoretical

Experimental Structures

PDB entries

Related Diseases

recorded

Function

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells

Amino Acid Sequence

MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT
DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK
HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA
IKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV

FASTA format · 640 amino acids · mass 72.3 kDa

Post-Translational Modifications

•Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation
•SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition
•Phosphorylated by NLK on multiple sites, which induces proteasomal degradation
•Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels