Ras-related protein R-Ras

Homo sapiensTaxon: 9606

3D-structureCell membraneDirect protein sequencingGTP-bindingHydrolaseLipoproteinMembraneMethylationNucleotide-bindingPalmitatePrenylationProteomics identification+1

Sequence Length

218

amino acids

Molecular Weight

23.5 kDa

theoretical

Experimental Structures

PDB entries

Related Diseases

recorded

Function

GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:39809765). Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267)

Amino Acid Sequence

MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDP
TIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVG
KLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVD
EAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL

FASTA format · 218 amino acids · mass 23.5 kDa

Experimental Structures

2 PDB entries

2FN47S0Z

Post-Translational Modifications

•S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability