P04040
CATA_HUMANCAT
Catalase
过氧化氢酶
Homo sapiensTaxon: 9606
3D-structureAcetylationDirect protein sequencingHemeHydrogen peroxideIronMetal-bindingMitogenNADPOxidoreductasePeroxidasePeroxisome+3
配列長
527
アミノ酸
分子量
59.8 kDa
理論値
実験構造
16
PDB エントリー
関連疾患
1
記録済み
機能記述
Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369)
催化过氧化物酶体氧化酶产生的过氧化氢 (H(2)O(2)) 降解为水和氧气，从而保护细胞免受过氧化氢的毒性作用 (PubMed:7882369)。 促进细胞生长，包括 T 细胞、B 细胞、骨髓性白血病细胞、黑色素瘤细胞、肥大细胞瘤细胞以及正常和转化的成纤维细胞 (PubMed:7882369)
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関連疾患
Acatalasemia
A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait.
アミノ酸配列
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
FASTA 形式 · 527 アミノ酸 · 分子量 59.8 kDa
実験構造
16 PDB エントリー1DGB1DGF1DGG1DGH1F4J1QQW7P8W7VD98EL98HID8PVD8SGV8WZH8WZJ8WZK8WZM