P08670
VIME_HUMANVIM
Vimentin
Homo sapiensTaxon: 9606
3D-structureAcetylationCataractCell membraneCell projectionCoiled coilCytoplasmCytoskeletonDirect protein sequencingDisease variantGlycoproteinHost-virus interaction+9
配列長
466
アミノ酸
分子量
53.7 kDa
理論値
実験構造
26
PDB エントリー
関連疾患
1
記録済み
機能記述
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity)
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2
波形蛋白是在各种非上皮细胞，尤其是间充质细胞中发现的 III 类中间丝。 波形蛋白附着在细胞核、内质网和线粒体的侧面或末端。 在细胞迁移前沿的细胞定向运动、方向、细胞片组织和高尔基复合体极化中发挥作用（通过相似性）。 保护 SCRIB 免受蛋白酶体降解，并促进其以细胞接触介导的方式定位到中间丝（通过相似性）。 可以通过 DSP 介导的募集到生长尖端来促进轴突生长和运动纤维修复（通过相似性）
参与 LARP6 稳定 CO1A1 和 CO1A2 的 I 型胶原蛋白 mRNA
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局在と分布
組織特異性
Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines
関連疾患
Cataract 30, multiple types
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
アミノ酸配列
MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGV YATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDK VRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAE DIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEE
FASTA 形式 · 466 アミノ酸 · 分子量 53.7 kDa
実験構造
26 PDB エントリー1GK41GK61GK73G1E3KLT3S4R3SSU3SWK3TRT3UF14MCY4MCZ4MD04MD54MDI4MDJ4YPC4YV35WHF6ATF6ATI6BIR6YXK8RVE8TRQ8TRR
翻訳後修飾
- •Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm (PubMed:21465480). Phosphorylated by STK33 (PubMed:18811945). Phosphorylated on tyrosine residues by SRMS (PubMed:29496907)
- •O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status
- •S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex