P08865
RSSA_HUMANRPSA
Small ribosomal subunit protein uS2
Homo sapiensTaxon: 9606
3D-structureAcetylationCell membraneCytoplasmDirect protein sequencingDisease variantHost cell receptor for virus entryHost-virus interactionIsopeptide bondMembraneNucleusPhosphoprotein+7
配列長
295
アミノ酸
分子量
32.9 kDa
理論値
実験構造
50
PDB エントリー
関連疾患
1
記録済み
機能記述
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA
(Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9
(Microbial infection) Acts as a receptor for the Dengue virus
(Microbial infection) Acts as a receptor for the Sindbis virus
(Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus
(Microbial infection) Acts as a receptor for the pathogenic prion protein
(Microbial infection) Acts as a receptor for bacteria
関連疾患
Asplenia, isolated congenital
A rare primary immunodeficiency and life-threatening condition, often presenting with pneumococcal sepsis. Most affected individuals die of severe bacterial infections in early childhood. Isolated asplenia is distinct from asplenia associated with other complex visceral defects, notably heterotaxy syndromes such as Ivemark syndrome.
アミノ酸配列
MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLL AARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPR LLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAR EVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTA
FASTA 形式 · 295 アミノ酸 · 分子量 32.9 kDa
実験構造
50 PDB エントリー3BCH4UG04V5Z4V6X5A2Q5AJ05FLX5LKS5OA35T2C5VYC6FEC6G186G4S6G516G536G5H6G5I6IP56IP66IP86OLE6OLF6OLG6OLI6OLZ6OM06OM76QZP6XA16Y0G6Y2L6Y576YBD6YBW6Z6L6Z6M6Z6N6ZLW6ZM76ZME6ZMI6ZMO6ZMT6ZMW6ZN56ZOJ6ZOK6ZON6ZP4
翻訳後修飾
- •Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863)
- •Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions