Galectin-1

Homo sapiensTaxon: 9606

3D-structureAcetylationApoptosisCytoplasmDirect protein sequencingExtracellular matrixLectinPhosphoproteinProteomics identificationReference proteomeSecreted

配列長

135

アミノ酸

分子量

14.7 kDa

理論値

実験構造

PDB エントリー

機能記述

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69 (PubMed:24752896)

局在と分布

組織特異性

Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells

アミノ酸配列

MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIV
CNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINY
MAADGDFKIKCVAFD

FASTA 形式 · 135 アミノ酸 · 分子量 14.7 kDa

実験構造

39 PDB エントリー

1GZW1W6M1W6N1W6O1W6P1W6Q2KM22ZKN3OY83OYW3T2T3W583W594Q1P4Q1R4Q264Q274Q2F4XBL4Y1U4Y1V4Y1X4Y1Y4Y1Z4Y204Y224Y245MWT5MWX6B946F836M5Y7LTA7NML8B0W8B0Z8OJP8R748RDC