Serglycin

Homo sapiensTaxon: 9606

ApoptosisBiomineralizationDirect protein sequencingDisulfide bondGlycoproteinGolgi apparatusLysosomeProteoglycanProteomics identificationReference proteomeRepeatSecreted+1

配列長

158

アミノ酸

分子量

17.7 kDa

理論値

実験構造

PDB エントリー

機能記述

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF and may also regulate protease secretion. Inhibits bone mineralization

アミノ酸配列

MMQKLLKCSRLVLALALILVLESSVQGYPTRRARYQWVRCNPDSNSANCLEEKGPMFELL
PGESNKIPRLRTDLFPKTRIQDLNRIFPLSEDYSGSGFGSGSGSGSGSGSGFLTEMEQDY
QLVDESDAFHDNLRSLDRNLPSDSQDLGQHGLEEDFML

FASTA 形式 · 158 アミノ酸 · 分子量 17.7 kDa

翻訳後修飾

•O-glycosylated; contains chondroitin sulfate and heparan sulfate