P10242
MYB_HUMANMYB
Transcriptional activator Myb
Homo sapiensTaxon: 9606
AcetylationActivatorAlternative splicingDNA-bindingIsopeptide bondNucleusPhosphoproteinProteomics identificationProto-oncogeneReference proteomeRepeatTranscription+2
配列長
640
アミノ酸
分子量
72.3 kDa
理論値
実験構造
0
PDB エントリー
関連疾患
0
記録済み
機能記述
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells
アミノ酸配列
MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA IKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV
FASTA 形式 · 640 アミノ酸 · 分子量 72.3 kDa
翻訳後修飾
- •Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation
- •SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition
- •Phosphorylated by NLK on multiple sites, which induces proteasomal degradation
- •Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels