Ras-related protein R-Ras

Homo sapiensTaxon: 9606

3D-structureCell membraneDirect protein sequencingGTP-bindingHydrolaseLipoproteinMembraneMethylationNucleotide-bindingPalmitatePrenylationProteomics identification+1

配列長

218

アミノ酸

分子量

23.5 kDa

理論値

実験構造

PDB エントリー

機能記述

GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:39809765). Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267)

アミノ酸配列

MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDP
TIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVG
KLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVD
EAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL

FASTA 形式 · 218 アミノ酸 · 分子量 23.5 kDa

実験構造

2 PDB エントリー

2FN47S0Z

翻訳後修飾

•S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability