Digital Me · Digital Body
What am I made of? = Flesh & Blood · Health
Not a report. A digital being born from your genome, taking root in compute like a planted seed. It is the foundation of digital twins—the neural data of Dimension 2 (Digital Mind) needs to couple with your genome; the digital human shell of Dimension 3 (Digital VR Me) needs Dimension 1 data as decision basis (injecting flesh); the cross-generational legacy of Dimension 4 (Digital Bloodline) needs your whole-genome data as content (injecting bloodline).
Without flesh, the shell is just a generic digital human. Digital Me = flesh.
Understand what your digital body is made of and how the five-layer architecture serves your health.
Evaluate verified pipelines for genome interpretation, neoantigen discovery, and structure prediction.
Assess the five-layer tech stack barriers and validation metrics.
Understand Your Digital Body in 5 Minutes
No biology background needed—build intuition in four steps
Your body is a book written in 3 billion letters—this is your genome (complete DNA sequence). Each letter is one of A, T, C, or G.
This book has spelling errors (mutations)—some are harmless, some may be disease-causing. Finding these errors and assessing their impact is genome interpretation.
Proteins are the machine parts translated from this book; 3D structure determines function. Wrong structure = wrong function = disease. Predicting protein 3D structure means seeing what the parts look like.
DiVo reads this book from start to finish: gene -> protein -> cell -> aging -> cross-generation—this is your digital body. Five layers, built progressively, causally linked.
The five layers are not independent. They are strung together by a causal thread:
Gene variant -> protein structure change -> cell signaling pathway perturbation -> tissue-level impact -> health changes you perceive
The cross-generational extension of these five layers points to Dimension 4 (Digital Bloodline).
Five-Layer Architecture
Source Code
✓ 已验证Complete sequence of 3 billion base pairs
One WGS sequencing + DiVoGenome three-model cross-interpretation. Your pharmacogenomic profile, recessive disease carrier screening, cancer genetic risk—all from VCF in one step.
Molecular Self-Portrait
✓ 已验证Your unique protein 3D sculptures
DiVoFold5 builds atomic-level 3D structures for ~10,000 of your variant proteins. pLDDT 95.4, ipTM 0.977—approaching X-ray crystallography precision. 400+ complex real-world validation.
Virtual Cell
🔬 探索性Run experiments on your digital cells
DiVoCell multi-cell 3D simulation + DiVoSignal signaling pathway solver—drag in drug molecules to see response, change gene parameters to observe pathway rewiring, adjust diet input to track microbiome dynamics.
Time Dimension
✓ 已验证View aging curves like stock charts
GrimAge + DunedinPACE epigenetic clocks—precision within ~2 years. Track your true aging rate quarterly. Does your aging rate actually change after lifestyle changes? This is data, not guesswork.
Cross-Generation
🔬 探索性3D family genome atlas
Visualization of pathogenic variant transmission paths from grandparents to grandchildren. Shared recessive pathogenic variants between you and your partner are highlighted. What risks might your child inherit—know before pregnancy. The cross-generational extension of these five layers—it points to Dimension 4.
Health Applications
Digital Me is not a "data museum"—it is a health decision engine
Tumor Neoantigen mRNA Vaccine
✓ 已验证8-step full pipeline—from VCF/BAM to mRNA sequence design. Three differentiators: pMHC 3D structure validation, 5-dimensional immunogenicity scoring, RNALens in-house fine-tuning. Industry first-tier mature pipeline.
CAR-T Cell Therapy
✓ 已验证Dual-channel target discovery + de novo Binder design + pMHC 3D structure validation—full dry-lab pipeline from VCF to CAR navigator design.
Pharmacogenomics
✓ 已验证Why does a drug work for you but not another? The answer is mostly written in your genome. Extracted directly from VCF.
Cancer Genetic Risk
✓ 已验证BRCA, TP53, APC, Lynch syndrome and other hereditary cancer susceptibility variants—precisely screened before you show any symptoms.
Personalized Nutrition
🔬 探索性DiVoSignal + gut-brain axis model—based on your genotype and microbiome data, simulate body response after dietary changes.
Recessive Disease Carrier Screening
✓ 已验证ACMG-recommended 100+ gene carrier screening, from VCF in one step. Essential for pre-pregnancy planning.
Digital Me and the Four-in-One
The five layers of Digital Me are the foundation of digital twins—and the flesh of Dimension 3 (Digital VR Me).
- Dimension 2 (Digital Mind) neural data needs to couple with your genome
- Dimension 3 (Digital VR Me) digital human shell needs Dimension 1 data as decision basis (injecting flesh)
- Dimension 4 (Digital Bloodline) cross-generational legacy needs your whole-genome data as content (injecting bloodline)
Without Digital Me, Dimension 3 is just a generic digital human, and Dimension 4 has no inheritable data foundation. Digital Me = flesh. Without flesh, the shell is just a generic digital human.
What We Explicitly Don't Do
Clear boundaries build trust
No "fortune-telling gene reports"
Genomes provide risk probabilities, not deterministic prophecies.
No "one-click treatment plans"
Treatment plans are decided by clinicians; we provide computational basis.
No "bundled checkup packages"
Each service is delivered independently, no forced bundling.
No "genetic discrimination"
All reports comply with genetic information non-discrimination principles.
Glossary
Technical terms on this page, explained at once
| Term | Definition |
|---|---|
| Genome | Your complete DNA sequence, ~3 billion base pairs |
| VCF | Variant Call Format, records your genetic variants |
| WGS/WES | Whole Genome/Exome Sequencing—WGS reads the whole book, WES only the coding regions |
| ANNOVAR | Gene variant annotation tool—labels the functional impact of each variant |
| MHC | Major Histocompatibility Complex, your immune "ID card" |
| pLDDT | Protein structure prediction confidence, >90 is high precision |
| ipTM | Protein-protein interaction confidence, >0.75 is high confidence |
| Epigenetic Clock | Estimates your biological age via DNA methylation patterns |
| GrimAge/DunedinPACE | Two validated epigenetic clock algorithms |
| CADD | Combined Annotation Dependent Depletion, comprehensive variant pathogenicity score |
CAPACITY TRACE
能力回溯
这项服务由哪些能力支撑——从硅片到你的场景
硅片(L1) → 模型(L2) → Agent(L3) → 管线(L4) → 你的场景