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HLA
HLA Typing
Dual-tool cross-validation · 4-digit resolution
OptiType + Polysolver dual-tool independent operation from different principles, cross-validated 4-digit HLA-I typing. Entry service for neoantigen pipeline Step 1 and CAR-T pipeline CT1--incorrect HLA typing invalidates the entire downstream pipeline.
3-5 days20K-50K/sampleCapability Coverage 90%
Pipeline Flow
End-to-end dry-computing loop
1
Sequencing Data QC
FastQC + Trimmomatic quality control and cleaning
2
OptiType HLA-I Typing
OptiType 1.5.0 RNA-seq/WES-based rapid HLA-I typing (4-digit resolution)
3
Polysolver Cross-validation
Polysolver v4 WES-based independent HLA-I typing algorithm
4
Dual-tool Consensus Determination
DiVo proprietary comparison logic, final HLA typing determined only when both tools agree + confidence annotation
Core Tools
OptiType 1.5.0Polysolver v4FastQCTrimmomatic
Core Advantages
Dual-tool Cross-validation
OptiType + Polysolver operate independently from different principles, single-tool false positives/negatives eliminated by cross-validation
4-digit Resolution
Precise to A*02:01 level, necessary input for MHC binding prediction--2-digit typing cannot distinguish subtype affinity differences
Capability Coverage
90%USER SCENE
How This Technology Serves Patients
B2B2C: Through hospitals/doctors, this pipeline reaches these end-user scenarios
Start Your Project HLA Typing
Start with just 1 project, no team needed.