Gut-Brain Axis
🔬 探索性Your gut knows what you're thinking
This is a dimension of Digital Me that hasn't been fully explored, but may be the one closest to your daily life. Your gut microbiome maintains continuous dialogue with your brain via the vagus nerve-this isn't just "probiotics are good for digestion."
Patients & Public
Understand how gut microbiota affects your mood and cognition
Medical Institutions / B2B
Evaluate computational capabilities for microbiome-gene-diet causal mapping
Investors / Peers
Evaluate differentiation and technology barriers of gut-brain axis computation
Understand the Gut-Brain Axis in 5 Minutes
No biology background needed, just 5 minutes
Your gut has ~100 trillion microorganisms-more than your own human cells
They're not passengers-your gut microbiota participates in digestion, synthesizes vitamins, trains the immune system, and even affects your mood
The gut and brain are directly connected via the vagus nerve-this is the physical channel of the "gut-brain axis"
Short-chain fatty acids (butyrate) produced by gut bacteria can cross the blood-brain barrier and affect neuroinflammation
90% of serotonin is produced in the gut-this "happiness hormone" isn't only in the brain
What DiVo does isn't selling probiotics-it's computing a causal map of your genotype, microbiome composition, and dietary structure together
Microbiome × Genes × Diet × Mood
Microbiome × Genes × Diet × Mood Causal Map
Trillions of microorganisms live in your gut. They don't just help digest food-they maintain continuous dialogue with your brain via the vagus nerve. Their short-chain fatty acids affect your serotonin levels. The norepinephrine you release during stress is "sensed" by certain pathogenic bacteria, activating virulence genes.
COMT / MAO / TPH Genotype × Microbiome Metagenomics
Knowing your neurotransmitter metabolism speed genotype, combined with gut microbiome metagenomic sequencing, you can see an unprecedented causal map: my genes × my microbiome × my diet × my mood state.
Short-Chain Fatty Acid Metabolism Modeling
Butyrate, propionate, acetate-these three SCFAs are core products of gut microbiota fermenting dietary fiber. Butyrate can cross the blood-brain barrier and suppress neuroinflammation; propionate is associated with behavior and sociality. Based on your microbiome composition and dietary input, model and predict SCFA production, establishing quantitative links with neuroinflammation markers.
Dietary Intervention Simulation
Given a target microbiome change, reverse-engineer dietary adjustment plans. For example: increase dietary fiber intake -> butyrate production rises -> neuroinflammation markers decrease. Not a vague "eat more vegetables" suggestion, but quantitative simulation based on your personal microbiome composition and genotype-how much to change, expected effects, where the uncertainty lies.
Probiotic Matching Simulation
We won't tell you probiotic therapy is certain-it's still in clinical research. But we can tell you: based on your personal multi-dimensional data, this strain combination matches your biological characteristics better than that one. If you're willing to try, we'll accompany you. Probiotics are dietary therapy, you don't need a prescription to buy them.
Deep Coupling with Digital Me
The gut-brain axis is the dimension of Digital Me closest to your daily life. Microbiome data, together with your genomic, proteomic, and aging trajectory data, forms a more complete causal chain.
Causal Map
This is the value of Digital Me: not making decisions for you, but enabling you to make more informed ones.
Genotype × Microbiome Interaction Map
How your genotype affects gut microbiota, and how microbiota in turn affects your neurotransmitters
| Gene Locus | Metabolic Pathway | Microbiome Effect | Mechanism |
|---|---|---|---|
| COMT Val158Met | Dopamine metabolism speed | Affects gut motility and microbiome composition | Val/Val type metabolizes fast, dopamine levels low, gut motility slows; Met/Met type metabolizes slow, dopamine high, motility increases, microbiome composition changes accordingly |
| MAO-A | Serotonin degradation | Affects gut serotonin levels and mood | MAO-A low-activity type degrades serotonin slowly, gut serotonin high, may be associated with anxiety and IBS |
| TPH1 / TPH2 | Serotonin synthesis | Gut (90%) vs central (10%) distribution | TPH1 for peripheral (gut) synthesis, TPH2 for central; 90% of serotonin produced in gut, but only TPH2-synthesized portion affects the brain |
| FUT2 secretor | Gut mucosa glycosylation | Determines Bifidobacterium colonization ability | FUT2 secretors express ABO blood group antigens on gut mucosa, providing colonization sites for Bifidobacterium; non-secretors have significantly lower Bifidobacterium abundance |
| MTHFR C677T | Folate metabolism | Affects homocysteine and gut microbiome diversity | TT type folate metabolism efficiency reduced 30-70%, homocysteine elevated, associated with decreased microbiome diversity and increased inflammation |
Probiotic therapy is still in clinical research. We won't claim it's certain. But based on your personal multi-dimensional data, we can tell you which strain combination better matches your biological characteristics. The risk is low enough that you can decide for yourself.
DiVo's Role in Gut-Brain Axis Computation
What We Can Do
- Genotype -> metabolic pathway modeling
- Microbiome metagenomics × genotype cross-analysis
- Dietary intervention plan simulation
- Short-chain fatty acid production prediction
- Personalized strain matching computation
What We Cannot Do
- Microbiome testing-requires partner-provided data
- Probiotic recommendations-we're not a supplement company
- Clinical diagnosis-we're a computation engine, not a hospital
Coupling with Dimension 1
- Genotype is Dimension 1 L1 data
- Microbiome data crosses with proteome (L2)
- Diet simulation runs in virtual cells (L3)
- Aging trajectory (L4) is affected by microbiome
What We Don't Do
Clear boundaries build reliable trust
No replacing psychiatric diagnosis--The gut-brain axis is a research frontier, not a clinical diagnostic tool
No claiming "probiotics cure depression"--Causality is far from established
No microbiome testing--We do computational analysis; samples are provided by partners
No supplement recommendations--We output causal maps, not product advertisements
Glossary
| Term | Definition |
|---|---|
| Gut-brain axis | Bidirectional communication system between gut and brain, via neural, immune, and metabolic pathways |
| Vagus nerve | The tenth cranial nerve, direct physical connection between gut and brain |
| Short-chain fatty acids | Metabolites produced by gut microbiota fermenting dietary fiber (butyrate/propionate/acetate) |
| Serotonin | A neurotransmitter, 90% produced in the gut, regulates mood and gut motility |
| COMT | Catechol-O-methyltransferase, catecholamine degrading enzyme, affects dopamine metabolism speed |
| MAO | Monoamine oxidase, degrades serotonin and dopamine |
| Metagenomics | The sum of all microbial genomes in an environment-used to analyze gut microbiome composition |
| Blood-brain barrier | Protective barrier between brain and blood circulation, some metabolites can cross |
| FUT2 | Fucosyltransferase 2, determines gut mucosa glycosylation type, affects microbiome colonization |
CAPACITY TRACE
能力回溯
这项服务由哪些能力支撑——从硅片到你的场景
硅片(L1) → 模型(L2) → Agent(L3) → 管线(L4) → 你的场景