Dry Computation Services
Dry-Computing Services
Neoantigen pipeline · VCF-Report · pMHC structure prediction · mRNA optimization · genome interpretation report · science communication--information carriers delivered to humans
PIPELINES
Six Dry-Computing Pipelines
From protein engineering to custom bioinformatics--end-to-end dry-computing loop
Protein Engineering
Four-model enzyme activity cross-validation, 7-step workflow
Structure prediction -> catalytic activity -> stability screening -> sequence design -> immunogenicity assessment, full-process dry-computing loop.
Gene Editing System Design
gRNA + whole-genome off-target scanning + gene optimization
Supports three Cas variants, gene optimization 4.93s/326aa. gRNA design + whole-genome off-target evaluation + codon optimization.
mRNA Vaccine / Drug Design
CDS + 5'UTR + 3'UTR full coverage
GEMORNA three-module design, three-tier UTR for different expression needs. Immunogenicity assessed at design stage.
Precision Oncology
WGS annotation -> scoring -> medication -> neoantigen
VUS triple-model scoring, traditional methods only label "variant of uncertain significance". Genetic risk -> screening -> medication -> MRD -> neoantigen full loop.
AI Drug Virtual Screening
Virtual screening + docking + ADMET
TorchANI neural network potential accuracy approaches DFT. Target -> binding pocket -> molecular docking -> candidate molecule end-to-end.
Custom Bioinformatics
639 scripts + 11 model repository, rapid assembly
Docker containerized delivery, clients can run independently. Requirements analysis -> pipeline design -> script development -> containerization.
CAR-T Cell Therapy Computing
Dual-channel target discovery + de novo Binder design + pMHC 3D structure validation
5-step dry-computing pipeline--HLA typing -> neoantigen screening -> immunogenicity assessment -> Binder de novo design -> structure validation. Breaks through traditional scFv limitations.
HLA Typing
Dual-tool cross-validation · 4-digit resolution
OptiType + Polysolver dual-tool independent operation from different principles, cross-validated 4-digit HLA-I typing. Entry service for neoantigen and CAR-T pipelines.
Genome Interpretation Report
VCF full-chain interpretation · bilingual triple-format
AlphaGenome + Genos + Evo2 triple-model cross pathogenicity prediction, 6-step full chain. Bilingual triple-format report (plain language + professional + technical appendix).
CROSS-LAYER
Cross-Layer Synergy
Dry-computing service L4 builds upon engines, models, and agents
Engine Layer
ESMFold / Boltz-2 / Protenix structure prediction engines, RVDon PF extension hardware acceleration
EnterModel Layer
AlphaFold3 / ProteinMPNN / DLKcat and 11 other dry-computing model repositories
EnterAgent Layer
Agent orchestration of multi-pipeline synergy, from structure prediction to medication report automation
EnterDeliver Your Next Project with Dry Computing
6 pipelines covering protein engineering to precision oncology--no need to maintain a team, start per project.