Ageless Beauty
✓ 已验证Genes & Beauty -- Reshaping the Science of Beauty with Computing
Health and longevity are the foundation; beauty is the growth engine. How your genes affect your beauty--collagen loss rate, photoaging sensitivity, hair loss risk, pigmentation tendency--is not vague "genetic destiny" but quantifiable percentile ranking. The same WGS data supports both health/longevity interpretation and beauty interpretation.
Beauty Seekers
Understand how your genes affect your beauty--which aesthetic treatments have good expected outcomes, which need caution
Aesthetic Clinics / Brands
Evaluate gene-level precision aesthetics and anti-aging peptide screening capabilities
Investors / Peers
Evaluate the differentiation barriers and market potential of the "Genes & Beauty" sector
Understand "Genes & Beauty" in 5 Minutes
Your beauty code is written in your genes--we can read it
Your skin aging speed is 60% determined by genes--MMP1 gene variant carriers lose collagen 40% faster than average
MC1R gene doesn't just determine red hair--its variants make you more sensitive to UV photoaging, with higher pigmentation risk after laser treatment
Androgenetic alopecia (AGA) is quantifiable--AR gene CAG repeat number + 5 risk loci = your hair loss probability
Collagen isn't just "take a supplement"--your COL1A1/COL3A1 genotype determines synthesis efficiency, different genotypes need different supplementation strategies
Trillions of microorganisms live on your skin surface--their composition is co-regulated by your HLA genotype and skin barrier gene (FLG)
DiVo doesn't sell skincare products--we compute causal maps combining your genotype, microbiome composition, and skin phenotype
High hairline ≠ hair loss--congenital high hairline areas simply have no hair follicles, drugs are ineffective. Follicle induction is the first "from-scratch" technology--using a five-factor combination to restart follicle morphogenesis on follicle-free skin
Four Dry-Computing Pipelines
Transforming A/T/C/G into commercial-grade aesthetic insights--from risk assessment to molecular screening to follicle neogenesis
Aesthetic Phenotype PRS
✓ 已验证How your genes affect your beauty--collagen loss rate, photoaging sensitivity, hair loss risk, pigmentation tendency, quantified as percentile ranking
Protein/Peptide Screening
✓ 已验证Finding anti-aging molecules in 3D space--MMPs inhibitors, collagen engineering, Sirtuin activators, providing molecular-level dry-computing screening for brands
Skin Microbiome + Host Genes
✓ 已验证Skin condition is a symbiotic result of genes and microbiome--16S/ITS microbiome data cross-mined with host immune genes
Follicle Induction Technology
🔬 探索性From repair to regeneration--using WNT10B+FGF9+Noggin+RSPO1+SHH-N five-factor combination to induce new follicles on follicle-free skin. ARM model: design only, no manufacturing
Causal Map
The same WGS data supports both health/longevity interpretation and beauty interpretation--marginal cost approaches zero.
Genotype × Aesthetic Phenotype Interaction Map
How your genes affect skin, hair, and aging
| Gene Locus | Metabolic Pathway | Aesthetic Impact | Mechanism |
|---|---|---|---|
| MMP1/MMP3/MMP9 | Matrix Metalloproteinase | Collagen degradation rate | MMP1 is the primary degrader of type I collagen; MMP1 promoter 1G/2G polymorphism affects expression level, 2G/2G type accelerates collagen loss by 30-40% |
| MC1R | Melanocortin 1 Receptor | Photoaging sensitivity + Pigmentation | MC1R R151C/R160Q/D294H variants weaken UV-induced melanin synthesis protection, accelerating photoaging, 2-3x pigmentation risk after laser |
| AR (CAG repeat) | Androgen Receptor | AGA risk | Males with CAG repeat ≤20 have significantly elevated AGA risk; combined with rs9296269 and 4 other risk loci, hair loss probability can be quantified |
| COL1A1/COL3A1 | Collagen Synthesis | Skin support structure maintenance | COL1A1 rs1800012 Sp1 binding site variant affects type I collagen transcription efficiency; COL3A1 variants affect skin elasticity |
| FLG | Filaggrin | Skin barrier function | FLG nonsense mutations (2282del4/R501X) cause filaggrin deficiency, fragile skin barrier, 2x increase in transepidermal water loss |
| SIRT1/SIRT6 | Sirtuin deacetylase | Core anti-aging regulation | SIRT1 regulates p53/FOXO/NF-κB anti-aging pathways; SIRT6 maintains telomeric heterochromatin stability--both are anti-aging drug targets |
| WNT10B/SHH/NOGGIN | Follicle morphogenesis signaling | Follicle induction potential | WNT10B is the master switch for follicle genesis, SHH initiates epithelial-mesenchymal interaction, Noggin antagonizes BMP to permit follicle formation--these three determine hairline position during embryogenesis and can be reactivated in adulthood |
Of the four Ageless Beauty pipelines, the core computing engines of Pipeline A (PRS), Pipeline B (peptide screening), and Pipeline C (microbiome) are verified. Pipeline D (follicle induction) has a verified core engine, but the engineering design of the five-factor combination is still exploratory. Aesthetic Phenotype PRS is a risk assessment tool, not a diagnosis. Current GWAS data is predominantly European; targets with insufficient East Asian coverage are clearly marked "needs validation".
✓ What We Can Do
- ✓GWAS-based polygenic risk scoring for aesthetic targets (Pipeline A verified)
- ✓Protein 3D structure prediction + Pro-Prime stability + BoltzGen all-atom design + ProteinMPNN sequence design (Pipeline B verified)
- ✓16S/ITS microbiome analysis (DADA2+MGnify) + host gene cross-mining (Pipeline C verified)
- ✓Chinese population calibration (GVM + NyuWa + WBBC)
- ✓B2B2C model--computing backbone for aesthetic/anti-aging institutions, not direct-to-consumer
- ✓Follicle induction five-factor structure prediction + engineering design (Pipeline D exploratory), IP licensing (ARM model)
✗ What We Don't Do
- ✗No clinical diagnosis--GBP is risk assessment, not dermatological diagnosis
- ✗No skincare product recommendations--we output causal maps, not product ads
- ✗No sequencing--we do computational analysis, samples provided by partners
- ✗No "gene editing for beauty"--gene editing is for genetic disease treatment, not aesthetics
- ✗No wet-lab experiments (follicle induction factor expression/purification/animal experiments delegated to partners)
- ✗Targets with insufficient East Asian GWAS coverage are marked "needs validation"
- ✗Follicle induction efficacy on human skin has not been validated by any team--this is frontier exploration
Glossary
| Abbr. | Full Name | Translation | Explanation |
|---|---|---|---|
| PRS | Polygenic Risk Score | Polygenic Risk Score | Aggregates small effects from multiple gene loci to quantify the overall genetic risk for a phenotype |
| MMP | Matrix Metalloproteinase | Matrix Metalloproteinase | Enzyme family that degrades extracellular matrix (including collagen), a core driver of skin aging |
| MC1R | Melanocortin 1 Receptor | Melanocortin 1 Receptor | Regulates melanin synthesis; variants cause light sensitivity and increased pigmentation risk |
| AGA | Androgenetic Alopecia | Androgenetic Alopecia | The most common hair loss type, co-regulated by AR gene and polygenic loci |
| GBP | Genetic Beauty Profile | Genetic Beauty Profile | Personalized "gene -> beauty" digital profile based on genomic data |
| FLG | Filaggrin | Filaggrin | Key skin barrier protein; mutations cause fragile barrier and transepidermal water loss |
| Sirtuin | Sirtuin family | Sirtuin family | NAD+-dependent protein deacetylases regulating aging, metabolism, and inflammation |
| Follicle Induction | Hair Follicle Neogenesis | Creating new follicles on follicle-free skin | Using WNT10B and other five factors to restart embryonic follicle morphogenesis--from scratch, not repair |
CAPACITY TRACE
能力回溯
这项服务由哪些能力支撑——从硅片到你的场景
Protein 3D structure prediction, pLDDT 95.4
BoltzGen (5 weights)All-atom diffusion design, 529M params
Pro-Prime/ProSSTProtein stability prediction SOTA
DiVoGenomeVariant annotation + PRS scoring + HLA typing
DiVoImmunoImmunogenicity assessment, MHC binding prediction
GEMORNAmRNA sequence design + stability prediction
硅片(L1) → 模型(L2) → Agent(L3) → 管线(L4) → 你的场景